To ensure long-term reliability for your Ford F-150, regular maintenance is key. Start with consistent oil changes every 5,000 to 7,500 miles to keep the engine running smoothly. Check and replace the air filter every 15,000 miles to maintain optimal fuel efficiency. Keep an eye on brake pads and tire rotations to prevent uneven wear. Regularly inspect the transmission fluid and coolant levels to avoid overheating and mechanical failures. When considering the best and worst years for Ford F-150, models with a well-documented maintenance history, like the 2012 F-150, tend to offer better reliability.